In the path of progress! Santee is located just 30 minutes from the Volvo Plant at Camp Hall and the Walmart Distribution Center in Ridgeville. New residential, commercial, and industrial development has arrived in Santee with additional development coming. Santee is home of the DP World Industrial Park and within 10 miles of the Matthews Industrial Park in Orangeburg. The Town of Santee is located on Lake Marion, South Carolina's largest freshwater body, which provides recreational opportunities for fishermen, boaters, and wildlife enthusiasts. 3 championship golf courses add to the available activities in this historic town. The SC Department of Parks and Recreation has a very popular park located in Santee on the lake. A great quality of life is to be found in Santee.